2023

A ciliary SMOOTHENED-GRK2-PKA signaling pathway initiates Hedgehog signal transduction
BioRxiv preprint. doi: https://doi.org/10.1101/2023.05.10.540226
Madison FW, Zhang J, Steiner W, Ku P, Zhu JF, Michaelson Z, Yen Y-C, Long A, Casey MJ, Poddar A, Nelson IB, Arveseth CD, Nagel F, Clough R, LaPotin S, Kwan KM, Schulz S, Stewart RA, Tesmer JJ, Caspary T, *Subramanian R, *Ge X, *Myers BR. *co-corresponding author

Hedgehog signaling in cortical development (Invited Review Article)
Special issue of “Hedgehog Signaling: Advances in Development and Cancer”, Cells. https://doi.org/10.3390/cells13010021
Cai E, Gonzalez Barba M, Ge X.

2022

A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction
Nature Structural & Molecular Biology, https://doi.org/10.1038/s41594-022-00838-z
Happ JT, Arveseth CD, Bruystens J, Bertinetti D, Nelson IB, Olivieri C, Zhang J, Hedeen DS, Zhu JF, Capener JL, Bröckel JW, Vu L, King CC, Ruiz-Perez VL, Ge X, Veglia G, Herberg FW, Taylor SS, Myers BR

Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway
BioRxiv preprint. doi: https://doi.org/10.1101/2022.10.10.511655
Liu X, Yam PT, Chen wJ, Schlienger S, Torres-Gutierrez O, Cai E, Zhang J, Ting AY, Branon TC, Leib R, Cayouette M, Charron F, Ge X.

2021

Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium. (Invited Review article)
SCIENCE CHINA Life Sciences, https://doi.org/10.1007/s11427-021-1975-9
Eva Cai, Jingyi Zhang, Xuecai Ge.

Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome.
Molecular Biology of the Cell, https://doi.org/10.1091/mbc.E21-02-0064
Hualing Peng, Jingyi Zhang, Amanda Ya, Winston Ma, Sammy Villa, Shahar Sukenik, Xuecai Ge.

2020

Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome.
BioRxiv preprint. doi: https://doi.org/10.1101/2020.04.24.059923
Hualing Peng, Jingyi Zhang, Amanda Ya, Winston Ma, Xuecai Ge.

2019

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.
Nat Cell Biol. 21 (5): 614-626. doi: 10.1038/s41556-019-0321-6
Gan L, Seki A, Shen K, Lyer H, Han K, Hayer A, Wollman R, Ge X, Lin JR, Dey G, Talbot WS, Meyer.

2018

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma.
Science Signaling. 11(547). pii: eaau5147. doi: 10.1126/scisignal.aau5147
Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP.

LEAP2 is an Endogenous Antagonist of the Ghrelin Receptor.
Cell Metabolism. 27:1-9. DOI: 10.1016/j.cmet.2017.10.016.
Ge X*, Yang H, Bednarek, MA, Galon-Tilleman H, Chen, P, Chen M, Lichtman, JS, Wang Y, Dalmas O, Yin Y, Tian H, Jermutus L, Grimsby J, Rondinone, CM, Konkar A, Kaplan, DD*. *Author of correspondence.

2017

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fate.
Nature. 544: 245-249. DOI: 10.1038/nature21722.
Mall M, Kareta MS, Chanda S, Ahlenius H, Perotti N, Zhou B, Grieder SD, Ge X, Drake S, Euong Ang C, Walker BM, Vierbuchen T, Fuentes DR, Brennecke P, Nitta KR, Jolma A, Steinmetz LM, Taipale J, Südhof TC, Wernig M.

2015

Integration of Neuropilin with Hedgehog signal transduction through control of Phosphodiesterase 4 and protein kinase A.
eLife. 4:e07068. DOI: 10.7554/eLife.07068.
Ge X, Milenkovic L, Suyama K, Hartl T, Winan A, Meyer T, Scott MP.

2010 – 2005

Control of ATF4 persistence by a gradient of phosphorylation is required for cell cycle progression and neurogenesis.
J. Biol. chem. 2010, 285:33324-37. https://doi.org/10.1074/jbc.M110.140699.
Frank CL, Ge X, Xie Z, Zhou Y, Tsai LH.

Centrosome motility is essential for initial axon formation in the neocortex.
J. Neurosci. 2010, 30:10391-406. DOI: 10.1523/JNEUROSCI.0381-10.2010.
de Anda FC, Meletis K, Ge X, Rei D, Tsai LH.

Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
Neuron. 2010, 67:33-48. DOI: 10.1016/j.neuron.2010.06.002.
Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH.

Guiding neuronal cell migrations.
Book chapter in Neuronal guidance: the biology of brain wiring (Tessier-Lavigne M and Kolodkin AL, eds.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 2010, pp291-310. DOI: 10.1101/cshperspect.a001834
Marín O, Valiente M, Ge X, Tsai LH.

Hook3 and PCM1 regulate neurogenesis by controlling the centrosome dynamics and interkinetic nuclear migration.
Neuron. 2010, 65:191-203. DOI: 10.1016/j.neuron.2010.01.011.
Ge X, Frank CL, Calderon de Anda F, Tsai LH.

DISC1 regulates neural progenitor proliferation via modulation of GSK3b/b-catenin signaling.
Cell. 2009, 136: 1017-31. https://doi.org/10.1016/j.cell.2008.12.044.
Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH.

The Heparan Sulfate Proteoglycans Dally-like and Syndecan Have Distinct Functions in Axon Guidance and Visual-System Assembly in Drosophila.
Curr. Biol. 2005, 15: 833-8. DOI: 10.1016/j.cub.2005.03.039.
Rawson JM, Dimitroff B, Johnson KG, Rawson JM, Ge X, Van Vactor D, Selleck SB.

Pre 2005

Notch Function in Drosophila Memory and Neuronal Plasticity.
Proc. Natl. Acad. Sci. USA. 2004, 101: 10172-6. https://doi.org/10.1073/pnas.0403497101.
Ge X, Hannan F, Xie Z, Feng C, Tully T, Zhou H, Xie Z, Zhong Y.

Effects of lesions of various brain areas on drug priming or footshock-induced reactivation of extinguished conditioned place preference.
Brain Res. 2002, 950 (1-2): 1-9. DOI: 10.1016/s0006-8993(02)02980-3.
Wang B, Luo F, Ge X, Fu AH, Han JS.